COBALT (Constraint based Multiple Alignment Tool) is a multiple sequence alignment tool that finds a collection of pairwise constraints derived from conserved domain database, protein motif database, and sequence similarity, using RPS-BLAST, BLASTP, and PHI-BLAST.

BioGRID interactions are recorded as relationships between two proteins or genes (i.e. they are binary relationships) with an evidence code that supports the interaction and a publication reference

Bridges is a heuristic search tool that uses short word matches to rapidly identify local similarities between sequences. It consists of three stages: filtering input sequences, identifying local similarities and post-processing local similarities.

Chemoinformatics plays a key role in areas as diverse as chemical genomics and drug discovery, the storage of chemical information in databases and the prediction of toxic substances. Today, these techniques are mostly used in pharmaceutical companies in the process of drug discovery, but also for example in “functional foods”, designed by nutritional companies to improve body functions, such as for example digestion or brain function.

Bioinformatics provides the computational support for functional genomics which will link the behavior of cells, organism amd population to the information encoded in the genomes, as well as structural genomics. The utility of bioinformatics lies in the identification of useful genes leading to the development of new gene products. The subject covers topics such as protein modeling and sequence alignment, expression data analysis, and comparartive genomics. It combines algorithmic, statistical and database methods for studying biological problems also.

Bioinformatics, the use of computer technology to manage biological information, made its spectacular debut a few years ago, as the first trickles of gene sequence information from the Human Genome Program (HGP) and other sequencing projects grew into a deluge. Individuals with the skills to work on the interface between molecular biology and computer science instantly became some of the most sought-after job applicants in the biopharma world. With about 3 billion base pairs on its agenda, and a target completion date of 2005, HGP alone should foster a continuing explosion of data and a robust job market for computational biologists.